Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.T389R

c.1166C>G

Surrounding Variants

13 papers

NM_139276.3

p.T389I

c.1166C>T

4 papers

NM_139276.3

p.T389S

c.1165A>T

3 papers

NM_139276.3

p.T389A

c.1165A>G

1 paper

NM_139276.3

p.G388A

c.1163G>C

1 paper

NM_139276.3

p.N390T

c.1169A>C

4 papers

NM_139276.3

p.L387R

c.1160T>G

2 papers

NM_139276.3

p.I386T

c.1157T>C

1 paper

NM_139276.3

p.I386N

c.1157T>A

32 papers

NM_139276.3

p.K392R

c.1175A>G

1 paper

NM_139276.3

p.K392N

c.1176A>T

9 papers

NM_139276.3

p.V393A

c.1178T>C

1 paper

NM_139276.3

p.N385H

c.1153A>C