Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.A119S

c.355G>T

Surrounding Variants

1 paper

NM_139276.3

p.T118T

c.354T>A

1 paper

NM_139276.3

p.Q117_T118del1

c.351_353delGTC

1 paper

NM_139276.3

p.C108_A119delFs

c.323_356del34

1 paper

NM_139276.3

p.T118S

c.352A>T

1 paper

NM_139276.3

p.T118A

c.352A>G

1 paper

NM_139276.3

p.Q117delFs

c.351delC

1 paper

NM_139276.3

p.A120V

c.359C>T

1 paper

NM_139276.3

p.A120A

c.360C>A

1 paper

NM_139276.3

p.Q117R

c.350A>G

1 paper

NM_139276.3

p.T121S

c.361A>T

1 paper

NM_139276.3

p.L116L

c.348A>G

1 paper

NM_139276.3

p.A122S

c.364G>T