Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.R107G

c.319C>G

Surrounding Variants

3 papers

NM_139276.3

p.R107W

c.319C>T

3 papers

NM_139276.3

p.R107Q

c.320G>A

1 paper

NM_139276.3

p.A106A

c.318C>T

2 papers

NM_139276.3

p.A106V

c.317C>T

1 paper

NM_139276.3

p.C108G

c.322T>G

2 papers

NM_139276.3

p.C108S

c.322T>A

2 papers

NM_139276.3

p.C108S

c.323G>C

1 paper

NM_139276.3

p.A102_C108insFs

c.304_323dup20

1 paper

NM_139276.3

p.C108*

c.324C>A

1 paper

NM_139276.3

p.L109R

c.326T>G

1 paper

NM_139276.3

p.L109L

c.327G>A

1 paper

NM_139276.3

p.R103R

c.309G>A