Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.W37R

c.109T>A

Surrounding Variants

1 paper

NM_139276.3

p.W37*

c.110G>A

1 paper

NM_139276.3

p.W37C

c.111G>C

1 paper

NM_139276.3

p.W37*

c.111G>A

1 paper

NM_139276.3

p.P36S

c.106C>T

1 paper

NM_139276.3

p.P36T

c.106C>A

1 paper

NM_139276.3

p.A35A

c.105C>T

1 paper

NM_139276.3

p.A35A

c.105C>A

1 paper

NM_139276.3

p.I38delFs

c.112_113delAT

2 papers

NM_139276.3

p.A35V

c.104C>T

1 paper

NM_139276.3

p.A35G

c.104C>G

1 paper

NM_139276.3

p.E39*

c.115G>T

2 papers

NM_139276.3

p.E39K

c.115G>A