Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.E29A

c.86A>C

Surrounding Variants

3 papers

NM_139276.3

p.R31W

c.91C>T

6 papers

NM_139276.3

p.R31Q

c.92G>A

1 paper

NM_139276.3

p.P27L

c.80C>T

2 papers

NM_139276.3

p.R31R

c.93G>A

1 paper

NM_139276.3

p.Q32*

c.94C>T

2 papers

NM_139276.3

p.Q32K

c.94C>A

1 paper

NM_139276.3

p.F26Y

c.77T>A

1 paper

NM_139276.3

p.Q32L

c.95A>T

1 paper

NM_139276.3

p.F26I

c.76T>A

7 papers

NM_139276.3

p.F33C

c.98T>G

1 paper

NM_139276.3

p.F33S

c.98T>C

1 paper

NM_139276.3

p.S25N

c.74G>A