Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.D24H

c.70G>C

Surrounding Variants

1 paper

NM_139276.3

p.S25G

c.73A>G

1 paper

NM_139276.3

p.S25N

c.74G>A

1 paper

NM_139276.3

p.Y22F

c.65A>T

1 paper

NM_139276.3

p.Y22D

c.64T>G

1 paper

NM_139276.3

p.F26I

c.76T>A

1 paper

NM_139276.3

p.F26Y

c.77T>A

1 paper

NM_139276.3

p.L21L

c.63C>T

1 paper

NM_139276.3

p.L21V

c.61C>G

3 papers

NM_139276.3

p.Q20Q

c.60G>A

1 paper

NM_139276.3

p.P27L

c.80C>T

1 paper

NM_139276.3

p.Q20*

c.58C>T

1 paper

NM_139276.3

p.H19R

c.56A>G