Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.Q9L

c.26A>T

Surrounding Variants

1 paper

NM_139276.3

p.Q9R

c.26A>G

1 paper

NM_139276.3

p.Q9H

c.27G>T

1 paper

NM_139276.3

p.Q9H

c.27G>C

1 paper

NM_139276.3

p.Q8Q

c.24G>A

1 paper

NM_139276.3

p.Q8R

c.23A>G

1 paper

NM_139276.3

p.Q8*

c.22C>T

1 paper

NM_139276.3

p.D11Y

c.31G>T

1 paper

NM_139276.3

p.D11H

c.31G>C

1 paper

NM_139276.3

p.D11N

c.31G>A

1 paper

NM_139276.3

p.L7L

c.21A>T

1 paper

NM_139276.3

p.L7P

c.20T>C

2 papers

NM_139276.3

p.D11G

c.32A>G