Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.M1ins1

c.1_2insAGA

Surrounding Variants

2 papers

NM_139276.3

p.M1T

c.2T>C

1 paper

NM_139276.3

p.M1I

c.3G>T

5 papers

NM_139276.3

p.M1insFs

c.2dupT

1 paper

NM_139276.3

p.M1_A2insFs

c.3_4insA

1 paper

NM_139276.3

p.M1I

c.3G>C

3 papers

NM_139276.3

p.M1I

c.3G>A

1 paper

NM_139276.3

p.M1V

c.1A>G

1 paper

NM_139276.3

p.A2P

c.4G>C

1 paper

NM_139276.3

p.A2T

c.4G>A

1 paper

NM_139276.3

p.A2V

c.5C>T

1 paper

NM_139276.3

p.A2fs

c.4_5fs

1 paper

NM_139276.3

p.Q3insFs

c.7_8insG