Varaico: Literature-Extracted Genetic Variants

STAT6

483 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated...

Pfam Domains

STAT_intaa 2–114UCSCSTAT protein, protein interaction domain

STAT_alphaaa 148–262UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 277–413UCSCSTAT protein, DNA binding domain

STAT_linkeraa 435–518UCSCSignal transducer and activator of transcription, linker domain

SH2aa 537–616UCSCSH2 domain

STAT6_Caa 655–847UCSCSTAT6 C-terminal

Gene Aliases

HGNC Name

signal transducer and activator of transcription 6

HGNC Alias Symbols

D12S1644; IL-4-STAT

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003153.5

p.N420S

c.1259A>G

Surrounding Variants

3 papers

NM_003153.5

p.N420T

c.1259A>C

1 paper

NM_003153.5

p.N420K

c.1260C>G

2 papers

NM_003153.5

p.N420K

c.1260C>A

1 paper

NM_003153.5

p.D419E

c.1257C>G

2 papers

NM_003153.5

p.D419E

c.1257C>A

6 papers

NM_003153.5

p.D419V

c.1256A>T

42 papers

NM_003153.5

p.D419G

c.1256A>G

2 papers

NM_003153.5

p.N421S

c.1262A>G

20 papers

NM_003153.5

p.D419A

c.1256A>C

2 papers

NM_003153.5

p.N417_D419delins

c.1249_1256delinsTACCAAGG

9 papers

NM_003153.5

p.N421K

c.1263T>G

9 papers

NM_003153.5

p.N421K

c.1263T>A