Varaico: Literature-Extracted Genetic Variants

STAT6

483 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated...

Pfam Domains

STAT_intaa 2–114UCSCSTAT protein, protein interaction domain

STAT_alphaaa 148–262UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 277–413UCSCSTAT protein, DNA binding domain

STAT_linkeraa 435–518UCSCSignal transducer and activator of transcription, linker domain

SH2aa 537–616UCSCSH2 domain

STAT6_Caa 655–847UCSCSTAT6 C-terminal

Gene Aliases

HGNC Name

signal transducer and activator of transcription 6

HGNC Alias Symbols

D12S1644; IL-4-STAT

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003153.5

p.H415N

c.1243C>A

Surrounding Variants

1 paper

NM_003153.5

p.G416C

c.1246G>T

3 papers

NM_003153.5

p.G416R

c.1246G>C

1 paper

NM_003153.5

p.V414I

c.1240G>A

2 papers

NM_003153.5

p.G416V

c.1247G>T

21 papers

NM_003153.5

p.N417Y

c.1249A>T

3 papers

NM_003153.5

p.N417D

c.1249A>G

4 papers

NM_003153.5

p.N417S

c.1250A>G

9 papers

NM_003153.5

p.D419Y

c.1255G>T

23 papers

NM_003153.5

p.D419H

c.1255G>C

27 papers

NM_003153.5

p.D419N

c.1255G>A

6 papers

NM_003153.5

p.D419V

c.1256A>T

42 papers

NM_003153.5

p.D419G

c.1256A>G