Varaico: Literature-Extracted Genetic Variants

STAT6

483 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated...

Pfam Domains

STAT_intaa 2–114UCSCSTAT protein, protein interaction domain

STAT_alphaaa 148–262UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 277–413UCSCSTAT protein, DNA binding domain

STAT_linkeraa 435–518UCSCSignal transducer and activator of transcription, linker domain

SH2aa 537–616UCSCSH2 domain

STAT6_Caa 655–847UCSCSTAT6 C-terminal

Gene Aliases

HGNC Name

signal transducer and activator of transcription 6

HGNC Alias Symbols

D12S1644; IL-4-STAT

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003153.5

p.G375A

c.1124G>C

Surrounding Variants

4 papers

NM_003153.5

p.G375R

c.1123G>C

3 papers

NM_003153.5

p.E377Q

c.1129G>C

14 papers

NM_003153.5

p.E377K

c.1129G>A

1 paper

NM_003153.5

p.E377D

c.1131G>T

1 paper

NM_003153.5

p.E377D

c.1131G>C

12 papers

NM_003153.5

p.E372K

c.1114G>A

2 papers

NM_003153.5

p.C371R

c.1111T>C

1 paper

NM_003153.5

p.R370fs

c.1108_1109fs

5 papers

NM_003153.5

p.E382Q

c.1144G>C

1 paper

NM_003153.5

p.E382K

c.1144G>A

1 paper

NM_003153.5

p.I368insFs

c.1102_1103insC

1 paper

NM_003153.5

p.L365F

c.1093C>T