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Varaico: Literature-Extracted Genetic Variants

Include likely false extractions

Gene:STK10

Variant:p.T130M

STK10

99 papers

RefSeq Summary

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like...

Pfam Domains

Pkinaseaa 36–294UCSCProtein kinase domain

PKKaa 587–725UCSCPolo kinase kinase

PKKaa 755–895UCSCPolo kinase kinase

Gene Aliases

HGNC Name

serine/threonine kinase 10

HGNC Alias Symbols

LOK; PRO2729

Papers

Position

RefSeq ID

Protein change

DNA change

Pfam

gnomAD

Selected Variant

1 paper

chr5:172117612 G>A

NM_005990.4

p.T130M

c.389C>T

Pkinase

Exome: 0.0% (AC=25, hom=0)Genome: 0.0% (AC=2, hom=0)16 overlapping SVs

Surrounding Variants

1 paper

chr5:172117615 A>G

NM_005990.4

p.L129P

c.386T>C

Pkinase

exact variant not in gnomAD16 overlapping SVs

1 paper

chr5:172117585 C>T

NM_005990.4

p.R139H

c.416G>A

Pkinase

Exome: 0.0% (AC=22, hom=0)Genome: 0.0% (AC=2, hom=0)17 overlapping SVs

1 paper

chr5:172117573 T>A

NM_005990.4

p.E143V

c.428A>T

Pkinase

exact variant not in gnomAD17 overlapping SVs

1 paper

chr5:172117518 G>A

NM_005990.4

p.G161G

c.483C>T

Pkinase

exact variant not in gnomAD17 overlapping SVs

1 paper

chr5:172117514 C>T

NM_005990.4

p.V163M

c.487G>A

Pkinase

Exome: 0.0% (AC=24, hom=0)Genome: n/a17 overlapping SVs

1 paper

chr5:172117483 A>C

NM_005990.4

p.L173R

c.518T>G

Pkinase

exact variant not in gnomAD17 overlapping SVs

1 paper

chr5:172107837 G>A

NM_005990.4

p.S179F

c.536C>T

Pkinase

exact variant not in gnomAD17 overlapping SVs

2 papers

chr5:172127391 C>T

NM_005990.4

p.V118M

c.352G>A

Pkinase

Exome: 0.0% (AC=81, hom=0)Genome: 0.0% (AC=9, hom=0)13 overlapping SVs

1 paper

chr5:172127414 A>G

NM_005990.4

p.I110T

c.329T>C

Pkinase

Exome: 0.0% (AC=46, hom=0)Genome: 0.0% (AC=3, hom=0)13 overlapping SVs

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."