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Varaico: Literature-Extracted Genetic Variants

Include likely false extractions

Gene:STK10

Variant:p.L85P

STK10

99 papers

RefSeq Summary

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like...

Pfam Domains

Pkinaseaa 36–294UCSCProtein kinase domain

PKKaa 587–725UCSCPolo kinase kinase

PKKaa 755–895UCSCPolo kinase kinase

Gene Aliases

HGNC Name

serine/threonine kinase 10

HGNC Alias Symbols

LOK; PRO2729

Papers

Position

RefSeq ID

Protein change

DNA change

Pfam

gnomAD

Selected Variant

2 papers

chr5:172156691 A>G

NM_005990.4

p.L85P

c.254T>C

Pkinase

exact variant not in gnomAD14 overlapping SVs

Surrounding Variants

1 paper

chr5:172156681 G>A

NM_005990.4

p.C88C

c.264C>T

Pkinase

Exome: 0.0% (AC=9, hom=0)Genome: 0.0% (AC=4, hom=0)14 overlapping SVs

1 paper

chr5:172156707 C>T

NM_005990.4

p.V80M

c.238G>A

Pkinase

Exome: 0.0% (AC=22, hom=1)Genome: 0.0% (AC=2, hom=0)14 overlapping SVs

2 papers

chr5:172156743 C>T

NM_005990.4

p.E68K

c.202G>A

Pkinase

exact variant not in gnomAD14 overlapping SVs

1 paper

chr5:172156639 G>A

NM_005990.4

p.H102H

c.306C>T

Pkinase

Exome: 0.0% (AC=13, hom=0)Genome: n/a14 overlapping SVs

1 paper

chr5:172156634 C>T

NM_005990.4

p.G104E

c.311G>A

Pkinase

Exome: n/aGenome: 0.0% (AC=1, hom=0)14 overlapping SVs

1 paper

chr5:172156751 T>A

NM_005990.4

p.K65I

c.194A>T

Pkinase

exact variant not in gnomAD14 overlapping SVs

1 paper

chr5:172156767 C>T

NM_005990.4

p.A60T

c.178G>A

Pkinase

exact variant not in gnomAD14 overlapping SVs

1 paper

chr5:172156788 C>G

NM_005990.4

p.A53P

c.157G>C

Pkinase

exact variant not in gnomAD14 overlapping SVs

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."