Varaico: Literature-Extracted Genetic Variants

Gene:STK11
Variant:p.R74S

STK11

2,183 papers

RefSeq Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with t...

Pfam Domains

Pkinaseaa 49–309UCSCProtein kinase domain

Gene Aliases

HGNC Name

serine/threonine kinase 11

HGNC Alias Symbols

PJS; LKB1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_000455.5
p.R74S
c.222G>C
Surrounding Variants
1 paper
NM_000455.5
p.R75_L80del6
c.223_239del18
1 paper
NM_000455.5
p.R75_K81delFs
c.225_243del19
1 paper
NM_000455.5
p.A76delFs
c.226delG
1 paper
NM_000455.5
p.R75_L80del0
c.224_238del15
1 paper
NM_000455.5
p.R74K
c.221G>A
1 paper
NM_000455.5
p.R74insFs
c.221_222insA
1 paper
NM_000455.5
p.R74M
c.221G>T
1 paper
NM_000455.5
p.R74W
c.220A>T
1 paper
NM_000455.5
p.R75_A76delFs
c.223_226del4
1 paper
NM_000455.5
p.R75M
c.224G>T
1 paper
NM_000455.5
p.C73W
c.219C>G
1 paper
NM_000455.5
p.C73Y
c.218G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."