TBC1 domain family member 20

C20orf140

dJ852M4.2

chromosome 20 open reading frame 140

TBC1 domain family, member 20

This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].

Varaico: Literature-Extracted Genetic Variants

TBC1D20

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol