Varaico: Literature-Extracted Genetic Variants

TBK1

739 papers

RefSeq Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB...

Pfam Domains

Pkinaseaa 9–299UCSCProtein kinase domain

TBK1_ULDaa 308–395UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–655UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

TANK binding kinase 1

HGNC Alias Symbol

NAK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_013254.4

p.L59fs

c.175_176fs

Surrounding Variants

1 paper

NM_013254.4

p.L59fs

c.175_176fs

4 papers

NM_013254.4

p.L59insFs

c.176dupT

1 paper

NM_013254.4

p.L59F

c.177G>C

1 paper

NM_013254.4

p.L59F

c.177G>T

1 paper

NM_013254.4

p.V58M

c.172G>A

1 paper

NM_013254.4

p.K61fs

c.181_182fs

1 paper

NM_013254.4

p.K61R

c.182A>G

1 paper

NM_013254.4

p.E57_V58del1

c.170_172delAAG

2 papers

NM_013254.4

p.F56S

c.167T>C

1 paper

NM_013254.4

p.F56C

c.167T>G

8 papers

NM_013254.4

p.L62P

c.185T>C

1 paper

NM_013254.4

p.N63fs

c.187_188fs