Varaico: Literature-Extracted Genetic Variants

TBK1

739 papers

RefSeq Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB...

Pfam Domains

Pkinaseaa 9–299UCSCProtein kinase domain

TBK1_ULDaa 308–395UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–655UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

TANK binding kinase 1

HGNC Alias Symbol

NAK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_013254.4

p.H64_K65insFs

c.192_193insG

Surrounding Variants

1 paper

NM_013254.4

p.N63K

c.189T>A

6 papers

NM_013254.4

p.N63S

c.188A>G

1 paper

NM_013254.4

p.N66Y

c.196A>T

1 paper

NM_013254.4

p.N66T

c.197A>C

1 paper

NM_013254.4

p.N66S

c.197A>G

1 paper

NM_013254.4

p.N63fs

c.187_188fs

8 papers

NM_013254.4

p.L62P

c.185T>C

1 paper

NM_013254.4

p.K61R

c.182A>G

1 paper

NM_013254.4

p.K61fs

c.181_182fs

1 paper

NM_013254.4

p.V68D

c.203T>A

1 paper

NM_013254.4

p.K69_L70delFs

c.207_210del4

1 paper

NM_013254.4

p.K69R

c.206A>G