Varaico: Literature-Extracted Genetic Variants

TBK1

739 papers

RefSeq Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB...

Pfam Domains

Pkinaseaa 9–299UCSCProtein kinase domain

TBK1_ULDaa 308–395UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–655UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

TANK binding kinase 1

HGNC Alias Symbol

NAK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_013254.4

p.S151C

c.452C>G

Surrounding Variants

10 papers

NM_013254.4

p.S151F

c.452C>T

1 paper

NM_013254.4

p.V152_Y153delFs

c.456_457delGT

1 paper

NM_013254.4

p.Q150P

c.449A>C

2 papers

NM_013254.4

p.Y153fs

c.457_458fs

1 paper

NM_013254.4

p.Y153C

c.458A>G

1 paper

NM_013254.4

p.Y153F

c.458A>T

1 paper

NM_013254.4

p.G149A

c.446G>C

1 paper

NM_013254.4

p.K154Q

c.460A>C

3 papers

NM_013254.4

p.K154R

c.461A>G

1 paper

NM_013254.4

p.K154N

c.462A>C

1 paper

NM_013254.4

p.K154N

c.462A>T

1 paper

NM_013254.4

p.D148N

c.442G>A