Varaico: Literature-Extracted Genetic Variants

TBK1

739 papers

RefSeq Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB...

Pfam Domains

Pkinaseaa 9–299UCSCProtein kinase domain

TBK1_ULDaa 308–395UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–655UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

TANK binding kinase 1

HGNC Alias Symbol

NAK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_013254.4

p.F299I

c.895T>A

Surrounding Variants

1 paper

NM_013254.4

p.F298L

c.894T>A

1 paper

NM_013254.4

p.F298L

c.894T>G

1 paper

NM_013254.4

p.A300_M309del10

c.898_926del30

1 paper

NM_013254.4

p.A300fs

c.898_899fs

1 paper

NM_013254.4

p.F298L

c.892T>C

2 papers

NM_013254.4

p.F299insFs

c.897dupT

1 paper

NM_013254.4

p.T302S

c.904A>T

1 paper

NM_013254.4

p.T302S

c.905C>G

7 papers

NM_013254.4

p.G294D

c.881G>A

3 papers

NM_013254.4

p.G294A

c.881G>C

2 papers

NM_013254.4

p.G294V

c.881G>T

2 papers

NM_013254.4

p.D304V

c.911A>T