Varaico: Literature-Extracted Genetic Variants

TBK1

739 papers

RefSeq Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB...

Pfam Domains

Pkinaseaa 9–299UCSCProtein kinase domain

TBK1_ULDaa 308–395UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–655UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

TANK binding kinase 1

HGNC Alias Symbol

NAK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

20 papers

NM_013254.4

p.R357Q

c.1070G>A

Surrounding Variants

1 paper

NM_013254.4

p.R357insFs

c.1071dupA

13 papers

NM_013254.4

p.R357*

c.1069C>T

3 papers

NM_013254.4

p.R358C

c.1072C>T

1 paper

NM_013254.4

p.R358fs

c.1072_1073fs

7 papers

NM_013254.4

p.R358H

c.1073G>A

1 paper

NM_013254.4

p.E355A

c.1064A>C

3 papers

NM_013254.4

p.E355K

c.1063G>A

1 paper

NM_013254.4

p.I353I

c.1059C>T

1 paper

NM_013254.4

p.I353T

c.1058T>C

4 papers

NM_013254.4

p.I353V

c.1057A>G

1 paper

NM_013254.4

p.L352P

c.1055T>C

1 paper

NM_013254.4

p.L352I

c.1054C>A