Varaico: Literature-Extracted Genetic Variants

TBK1

739 papers

RefSeq Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB...

Pfam Domains

Pkinaseaa 9–299UCSCProtein kinase domain

TBK1_ULDaa 308–395UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–655UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

TANK binding kinase 1

HGNC Alias Symbol

NAK

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_013254.4

p.K622fs

c.1864_1865fs

Surrounding Variants

1 paper

NM_013254.4

p.K622R

c.1865A>G

2 papers

NM_013254.4

p.K622_L624delFs

c.1866_1872del7

2 papers

NM_013254.4

p.R621Splc

c.1863-1G>A

1 paper

NM_013254.4

p.K622K

c.1866G>A

1 paper

NM_013254.4

p.K622N

c.1866G>C

1 paper

NM_013254.4

p.K622N

c.1866G>T

3 papers

NM_013254.4

p.M623_H625delFs

c.1869_1875del7

2 papers

NM_013254.4

p.M623fs

c.1867_1868fs

1 paper

NM_013254.4

p.M623fs

c.1867_1868fs

1 paper

NM_013254.4

p.K628R

c.1883A>G

6 papers

NM_013254.4

p.Q629fs

c.1885_1886fs

1 paper

NM_013254.4

p.Q629fs

c.1885_1886fs