Varaico: Literature-Extracted Genetic Variants

TCF7L2

535 papers

RefSeq Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Gene...

Pfam Domains

CTNNB1_bindingaa 1–76UCSCN-terminal CTNNB1 binding

CTNNB1_bindingaa 5–236UCSCN-terminal CTNNB1 binding

HMG_boxaa 327–395UCSCHMG (high mobility group) box

ZNF704_Caa 423–452UCSCZinc finger protein 704 C-terminal domain

Gene Aliases

HGNC Name

transcription factor 7 like 2

HGNC Alias Symbol

TCF-4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001367943.1

p.Q3*

c.7C>T

Surrounding Variants

1 paper

NM_001367943.1

p.L4_N5insAGG

c.10_14ins9

1 paper

NM_001367943.1

p.L4L

c.10C>T

1 paper

NM_001367943.1

p.M1_P2insFs

c.3_4insA

1 paper

NM_001367943.1

p.M1_P2insFs

c.3_4insT

3 papers

NM_001367943.1

p.L4L

c.12G>A

2 papers

NM_001367943.1

p.L4L

c.12G>C

2 papers

NM_001367943.1

p.M1T

c.2T>C

1 paper

NM_001367943.1

p.N5insFs

c.13_14insC

1 paper

NM_001367943.1

p.N5insFs

c.13_14ins23

1 paper

NM_001367943.1

p.M1L

c.1A>C

1 paper

NM_001367943.1

p.M1L

c.1A>T

1 paper

NM_001367943.1

p.N5S

c.14A>G