Varaico: Literature-Extracted Genetic Variants

TCF7L2

535 papers

RefSeq Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Gene...

Pfam Domains

CTNNB1_bindingaa 1–76UCSCN-terminal CTNNB1 binding

CTNNB1_bindingaa 5–236UCSCN-terminal CTNNB1 binding

HMG_boxaa 327–395UCSCHMG (high mobility group) box

ZNF704_Caa 423–452UCSCZinc finger protein 704 C-terminal domain

Gene Aliases

HGNC Name

transcription factor 7 like 2

HGNC Alias Symbol

TCF-4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001367943.1

p.S20F

c.59C>T

Surrounding Variants

1 paper

NM_001367943.1

p.F21I

c.61T>A

1 paper

NM_001367943.1

p.F21L

c.61T>C

1 paper

NM_001367943.1

p.S20insFs

c.58dupT

1 paper

NM_001367943.1

p.I19F

c.55A>T

1 paper

NM_001367943.1

p.F21L

c.63C>A

1 paper

NM_001367943.1

p.F21L

c.63C>G

1 paper

NM_001367943.1

p.K22delFs

c.64_65delAA

1 paper

NM_001367943.1

p.L18L

c.54G>A

1 paper

NM_001367943.1

p.E17A

c.50A>C

1 paper

NM_001367943.1

p.D23A

c.68A>C

1 paper

NM_001367943.1

p.E17K

c.49G>A

1 paper

NM_001367943.1

p.E17delFs

c.51delA