Varaico: Literature-Extracted Genetic Variants

TCF7L2

535 papers

RefSeq Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Gene...

Pfam Domains

CTNNB1_bindingaa 1–76UCSCN-terminal CTNNB1 binding

CTNNB1_bindingaa 5–236UCSCN-terminal CTNNB1 binding

HMG_boxaa 327–395UCSCHMG (high mobility group) box

ZNF704_Caa 423–452UCSCZinc finger protein 704 C-terminal domain

Gene Aliases

HGNC Name

transcription factor 7 like 2

HGNC Alias Symbol

TCF-4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001367943.1

p.K30N

c.90G>C

Surrounding Variants

1 paper

NM_001367943.1

p.K30K

c.90G>A

1 paper

NM_001367943.1

p.K30N

c.90G>T

1 paper

NM_001367943.1

p.K30_S31insFs

c.90_91insG

1 paper

NM_001367943.1

p.S31G

c.91A>G

1 paper

NM_001367943.1

p.S31C

c.91A>T

1 paper

NM_001367943.1

p.E29E

c.87G>A

1 paper

NM_001367943.1

p.E29A

c.86A>C

1 paper

NM_001367943.1

p.S32P

c.94T>C

1 paper

NM_001367943.1

p.S32S

c.96C>T

1 paper

NM_001367943.1

p.E28D

c.84G>C

1 paper

NM_001367943.1

p.E28D

c.84G>T

1 paper

NM_001367943.1

p.E28A

c.83A>C