Varaico: Literature-Extracted Genetic Variants

TCF7L2

535 papers

RefSeq Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Gene...

Pfam Domains

CTNNB1_bindingaa 1–76UCSCN-terminal CTNNB1 binding

CTNNB1_bindingaa 5–236UCSCN-terminal CTNNB1 binding

HMG_boxaa 327–395UCSCHMG (high mobility group) box

ZNF704_Caa 423–452UCSCZinc finger protein 704 C-terminal domain

Gene Aliases

HGNC Name

transcription factor 7 like 2

HGNC Alias Symbol

TCF-4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001367943.1

p.L203P

c.608T>C

Surrounding Variants

3 papers

NM_001367943.1

p.T201M

c.602C>T

1 paper

NM_001367943.1

p.L200fs

c.598_599fs

1 paper

NM_001367943.1

p.P199H

c.596C>A

2 papers

NM_001367943.1

p.P199L

c.596C>T

1 paper

NM_001367943.1

p.H198H

c.594C>T

1 paper

NM_001367943.1

p.H198delFs

c.594delC

2 papers

NM_001367943.1

p.H198N

c.592C>A

1 paper

NM_001367943.1

p.H198Y

c.592C>T

1 paper

NM_001367943.1

p.E209K

c.625G>A

1 paper

NM_001367943.1

p.V197insFs

c.591dupC

1 paper

NM_001367943.1

p.H196Y

c.586C>T

1 paper

NM_001367943.1

p.F211V

c.631T>G