Varaico: Literature-Extracted Genetic Variants

TCF7L2

535 papers

RefSeq Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Gene...

Pfam Domains

CTNNB1_bindingaa 1–76UCSCN-terminal CTNNB1 binding

CTNNB1_bindingaa 5–236UCSCN-terminal CTNNB1 binding

HMG_boxaa 327–395UCSCHMG (high mobility group) box

ZNF704_Caa 423–452UCSCZinc finger protein 704 C-terminal domain

Gene Aliases

HGNC Name

transcription factor 7 like 2

HGNC Alias Symbol

TCF-4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_001367943.1

p.K462delFs

c.1385delA

Surrounding Variants

2 papers

NM_001367943.1

p.K462insFs

c.1385dupA

2 papers

NM_001367943.1

p.K462fs

c.1384_1385fs

7 papers

NM_001367943.1

p.K462fs

c.1384_1385fs

1 paper

NM_001367943.1

p.P461insFs

c.1381dupC

1 paper

NM_001367943.1

p.S459S

c.1377C>T

1 paper

NM_001367943.1

p.S459C

c.1375A>T

1 paper

NM_001367943.1

p.C464Y

c.1391G>A

1 paper

NM_001367943.1

p.R465fs

c.1393_1394fs

5 papers

NM_001367943.1

p.R465*

c.1393C>T

1 paper

NM_001367943.1

p.R465insFs

c.1394_1395insA

1 paper

NM_001367943.1

p.R465L

c.1394G>T

1 paper

NM_001367943.1

p.R467C

c.1399C>T