Varaico: Literature-Extracted Genetic Variants

THOC2

109 papers

RefSeq Summary

The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded ...

Pfam Domains

THOC2_Naa 8–426UCSCTHO complex subunit 2 N-terminus

THOC2_Naa 415–566UCSCTHO complex subunit 2 N-terminus

Thoc2aa 568–643UCSCTranscription- and export-related complex subunit

Tho2aa 873–1173UCSCTranscription factor/nuclear export subunit protein 2

Gene Aliases

HGNC Name

THO complex subunit 2

HGNC Previous Symbols

MRX12; MRX35

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001081550.2

p.P654T

c.1960C>A

Surrounding Variants

1 paper

NM_001081550.2

p.R651C

c.1951C>T

1 paper

NM_001081550.2

p.A658S

c.1972G>T

1 paper

NM_001081550.2

p.G659S

c.1975G>A

1 paper

NM_001081550.2

p.L660I

c.1978C>A

1 paper

NM_001081550.2

p.Q662R

c.1985A>G

2 papers

NM_001081550.2

p.N666D

c.1996A>G

1 paper

NM_001081550.2

p.E624A

c.1871A>C

1 paper

NM_001081550.2

p.Q684fs

c.2050_2051fs

1 paper

NM_001081550.2

p.M686fs

c.2056_2057fs

1 paper

NM_001081550.2

p.Q684insFs

c.2051_2052insA

2 papers

NM_001081550.2

p.T696I

c.2087C>T

1 paper

NM_001081550.2

p.D610N

c.1828G>A