Varaico: Literature-Extracted Genetic Variants

TIAM2

108 papers

RefSeq Summary

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (G...

Pfam Domains

PHaa 507–620UCSCPH domain

Tiam_CC_Exaa 645–742UCSCT-lymphoma invasion and metastasis CC-Ex domain

PDZaa 890–972UCSCPDZ domain

RhoGEFaa 1103–1291UCSCRhoGEF domain

PH_Tiam1aa 1300–1470UCSCTiam1 second PH domain-like

Gene Aliases

HGNC Name

TIAM Rac1 associated GEF 2

HGNC Alias Symbol

STEF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_012454.4

p.G2S

c.4G>A

Surrounding Variants

1 paper

NM_012454.4

p.T9I

c.26C>T

1 paper

NM_012454.4

p.R33C

c.97C>T

1 paper

NM_012454.4

p.G45R

c.133G>A

1 paper

NM_012454.4

p.G45R

c.133G>C

1 paper

NM_012454.4

p.H48_G49ins4

c.144_145ins12

1 paper

NM_012454.4

p.N51K

c.153C>A

1 paper

NM_012454.4

p.N51K

c.153C>G

1 paper

NM_012454.4

p.G52R

c.154G>A

1 paper

NM_012454.4

p.G52R

c.154G>C

1 paper

NM_012454.4

p.K69N

c.207G>C

1 paper

NM_012454.4

p.K69N

c.207G>T

1 paper

NM_012454.4

p.R87T

c.260G>C