Varaico: Literature-Extracted Genetic Variants

TIAM2

108 papers

RefSeq Summary

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (G...

Pfam Domains

PHaa 507–620UCSCPH domain

Tiam_CC_Exaa 645–742UCSCT-lymphoma invasion and metastasis CC-Ex domain

PDZaa 890–972UCSCPDZ domain

RhoGEFaa 1103–1291UCSCRhoGEF domain

PH_Tiam1aa 1300–1470UCSCTiam1 second PH domain-like

Gene Aliases

HGNC Name

TIAM Rac1 associated GEF 2

HGNC Alias Symbol

STEF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_012454.4

p.A624T

c.1870G>A

Surrounding Variants

1 paper

NM_012454.4

p.L633M

c.1897C>A

1 paper

NM_012454.4

p.A614V

c.1841C>T

1 paper

NM_012454.4

p.S651C

c.1951A>T

1 paper

NM_012454.4

p.Y598C

c.1793A>G

1 paper

NM_012454.4

p.D596N

c.1786G>A

2 papers

NM_012454.4

p.S557S

c.1671C>A