Varaico: Literature-Extracted Genetic Variants

Gene:TLR2
Variant:p.G100D

TLR2

1,316 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 76–135UCSCLeucine rich repeat
LRRCTaa 561–586UCSCLeucine rich repeat C-terminal domain
TIRaa 640–783UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 2

HGNC Alias Symbols

TIL4; CD282

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_001318789.2
p.G100D
c.299G>A
Surrounding Variants
1 paper
NM_001318789.2
p.S98A
c.292T>G
1 paper
NM_001318789.2
p.E103G
c.308A>G
1 paper
NM_001318789.2
p.D106G
c.317A>G
1 paper
NM_001318789.2
p.D106D
c.318C>T
1 paper
NM_001318789.2
p.E93E
c.279A>G
1 paper
NM_001318789.2
p.I91V
c.271A>G
1 paper
NM_001318789.2
p.T90A
c.268A>G
3 papers
NM_001318789.2
p.N89D
c.265A>G
1 paper
NM_001318789.2
p.Y111*
c.333C>A
1 paper
NM_001318789.2
p.S113P
c.337T>C
1 paper
NM_001318789.2
p.N86S
c.257A>G
1 paper
NM_001318789.2
p.N114I
c.341A>T
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