Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.A69S

c.205G>T

Surrounding Variants

3 papers

NM_003265.3

p.A69T

c.205G>A

1 paper

NM_003265.3

p.L66F

c.198A>C

1 paper

NM_003265.3

p.Q76K

c.226C>A

1 paper

NM_003265.3

p.N61T

c.182A>C

1 paper

NM_003265.3

p.L77P

c.230T>C

1 paper

NM_003265.3

p.T78S

c.233C>G

4 papers

NM_003265.3

p.T59N

c.176C>A

1 paper

NM_003265.3

p.D81G

c.242A>G

1 paper

NM_003265.3

p.V82E

c.245T>A

1 paper

NM_003265.3

p.T51R

c.152C>G

1 paper

NM_003265.3

p.P50T

c.148C>A

1 paper

NM_003265.3

p.S88T

c.262T>A