Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003265.3

p.T123M

c.368C>T

Surrounding Variants

1 paper

NM_003265.3

p.T123R

c.368C>G

1 paper

NM_003265.3

p.C122S

c.365G>C

1 paper

NM_003265.3

p.C122S

c.364T>A

1 paper

NM_003265.3

p.N124N

c.372T>C

1 paper

NM_003265.3

p.L125V

c.373T>G

1 paper

NM_003265.3

p.T126I

c.377C>T

1 paper

NM_003265.3

p.L128V

c.382C>G

1 paper

NM_003265.3

p.D116E

c.348T>A

1 paper

NM_003265.3

p.D116E

c.348T>G

3 papers

NM_003265.3

p.D116N

c.346G>A

2 papers

NM_003265.3

p.E110K

c.328G>A

1 paper

NM_003265.3

p.N109S

c.326A>G