Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.G221R

c.661G>C

Surrounding Variants

1 paper

NM_003265.3

p.G221R

c.661G>A

4 papers

NM_003265.3

p.A219T

c.655G>A

1 paper

NM_003265.3

p.C216*

c.648T>A

2 papers

NM_003265.3

p.F227I

c.679T>A

1 paper

NM_003265.3

p.S213C

c.638C>G

1 paper

NM_003265.3

p.N230fs

c.688_689fs

1 paper

NM_003265.3

p.E211_F212Splc

c.634-10C>A

1 paper

NM_003265.3

p.T238K

c.713C>A

1 paper

NM_003265.3

p.T238R

c.713C>G

2 papers

NM_003265.3

p.K240T

c.719A>C

1 paper

NM_003265.3

p.T248A

c.742A>G

1 paper

NM_003265.3

p.S254P

c.760T>C