Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_003265.3

p.F303S

c.908T>C

Surrounding Variants

1 paper

NM_003265.3

p.F304S

c.911T>C

1 paper

NM_003265.3

p.L305V

c.913C>G

10 papers

NM_003265.3

p.Y307D

c.919T>G

2 papers

NM_003265.3

p.Q299R

c.896A>G

18 papers

NM_003265.3

p.L297V

c.889C>G

1 paper

NM_003265.3

p.L313L

c.939G>A

1 paper

NM_003265.3

p.S293P

c.877T>C

1 paper

NM_003265.3

p.N291D

c.871A>G

1 paper

NM_003265.3

p.L318*

c.953T>A

1 paper

NM_003265.3

p.F322delFs

c.965delT

1 paper

NM_003265.3

p.F322fs

c.964_965fs

1 paper

NM_003265.3

p.N284S

c.851A>G