Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003265.3

p.T334S

c.1000A>T

Surrounding Variants

2 papers

NM_003265.3

p.T334S

c.1001C>G

2 papers

NM_003265.3

p.F333L

c.999T>G

1 paper

NM_003265.3

p.S332Y

c.995C>A

1 paper

NM_003265.3

p.Q336insFs

c.1007_1008insC

1 paper

NM_003265.3

p.R331W

c.991C>T

1 paper

NM_003265.3

p.S337N

c.1010G>A

6 papers

NM_003265.3

p.S339fs

c.1015_1016fs

4 papers

NM_003265.3

p.Y326N

c.976T>A

1 paper

NM_003265.3

p.F322fs

c.964_965fs

1 paper

NM_003265.3

p.F322delFs

c.965delT

1 paper

NM_003265.3

p.L318*

c.953T>A

1 paper

NM_003265.3

p.S350F

c.1049C>T