Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_003265.3

p.L360P

c.1079T>C

Surrounding Variants

2 papers

NM_003265.3

p.N361S

c.1082A>G

1 paper

NM_003265.3

p.L354P

c.1061T>C

1 paper

NM_003265.3

p.Q352insFs

c.1054dupC

1 paper

NM_003265.3

p.F351I

c.1051T>A

1 paper

NM_003265.3

p.S350F

c.1049C>T

4 papers

NM_003265.3

p.M374T

c.1121T>C

1 paper

NM_003265.3

p.T376R

c.1127C>G

1 paper

NM_003265.3

p.G377E

c.1130G>A

1 paper

NM_003265.3

p.L381P

c.1142T>C

6 papers

NM_003265.3

p.S339fs

c.1015_1016fs

1 paper

NM_003265.3

p.S337N

c.1010G>A

1 paper

NM_003265.3

p.Q336insFs

c.1007_1008insC