Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.L438Q

c.1313T>A

Surrounding Variants

1 paper

NM_003265.3

p.D437E

c.1311C>A

1 paper

NM_003265.3

p.D437E

c.1311C>G

1 paper

NM_003265.3

p.E442K

c.1324G>A

1 paper

NM_003265.3

p.E442A

c.1325A>C

1 paper

NM_003265.3

p.E442D

c.1326A>C

2 papers

NM_003265.3

p.E442D

c.1326A>T

2 papers

NM_003265.3

p.H432R

c.1295A>G

1 paper

NM_003265.3

p.G449fs

c.1345_1346fs

1 paper

NM_003265.3

p.E451V

c.1352A>T

1 paper

NM_003265.3

p.G454C

c.1360G>T

1 paper

NM_003265.3

p.I422T

c.1265T>C

1 paper

NM_003265.3

p.L455L

c.1363C>T