Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.R489S

c.1467G>T

Surrounding Variants

1 paper

NM_003265.3

p.R489S

c.1467G>C

4 papers

NM_003265.3

p.R488*

c.1462C>T

1 paper

NM_003265.3

p.R484*

c.1450C>T

1 paper

NM_003265.3

p.Q483*

c.1447C>T

1 paper

NM_003265.3

p.S497G

c.1489A>G

1 paper

NM_003265.3

p.S498C

c.1493C>G

1 paper

NM_003265.3

p.P499T

c.1495C>A

1 paper

NM_003265.3

p.L478L

c.1432T>C

1 paper

NM_003265.3

p.L505H

c.1514T>A

1 paper

NM_003265.3

p.R506C

c.1516C>T

1 paper

NM_003265.3

p.Q470K

c.1408C>A

1 paper

NM_003265.3

p.I510V

c.1528A>G