Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.N515D

c.1543A>G

Surrounding Variants

1 paper

NM_003265.3

p.N515K

c.1545C>A

1 paper

NM_003265.3

p.N515K

c.1545C>G

1 paper

NM_003265.3

p.L513I

c.1537C>A

1 paper

NM_003265.3

p.I518V

c.1552A>G

1 paper

NM_003265.3

p.I510V

c.1528A>G

1 paper

NM_003265.3

p.N520S

c.1559A>G

1 paper

NM_003265.3

p.I521T

c.1562T>C

1 paper

NM_003265.3

p.R506C

c.1516C>T

1 paper

NM_003265.3

p.D524E

c.1572C>A

1 paper

NM_003265.3

p.D524E

c.1572C>G

1 paper

NM_003265.3

p.L505H

c.1514T>A

1 paper

NM_003265.3

p.M525L

c.1573A>C