Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003265.3

p.L545P

c.1634T>C

Surrounding Variants

1 paper

NM_003265.3

p.W546*

c.1637G>A

1 paper

NM_003265.3

p.W546*

c.1638G>A

1 paper

NM_003265.3

p.Q538P

c.1613A>C

1 paper

NM_003265.3

p.Q538L

c.1613A>T

54 papers

NM_003265.3

p.P554S

c.1660C>T

1 paper

NM_003265.3

p.K531N

c.1593A>C

1 paper

NM_003265.3

p.K531N

c.1593A>T

1 paper

NM_003265.3

p.K531E

c.1591A>G

1 paper

NM_003265.3

p.L529P

c.1586T>C

1 paper

NM_003265.3

p.L529F

c.1585C>T

1 paper

NM_003265.3

p.E527K

c.1579G>A

1 paper

NM_003265.3

p.M525L

c.1573A>C