Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.I566V

c.1696A>G

Surrounding Variants

1 paper

NM_003265.3

p.I566N

c.1697T>A

1 paper

NM_003265.3

p.E570G

c.1709A>G

2 papers

NM_003265.3

p.N572S

c.1715A>G

1 paper

NM_003265.3

p.D575H

c.1723G>C

1 paper

NM_003265.3

p.D575A

c.1724A>C

54 papers

NM_003265.3

p.P554S

c.1660C>T

1 paper

NM_003265.3

p.W546*

c.1638G>A

1 paper

NM_003265.3

p.W546*

c.1637G>A

2 papers

NM_003265.3

p.L545P

c.1634T>C

1 paper

NM_003265.3

p.I591T

c.1772T>C

5 papers

NM_003265.3

p.D592N

c.1774G>A

1 paper

NM_003265.3

p.Q538P

c.1613A>C