Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.R643H

c.1928G>A

Surrounding Variants

1 paper

NM_003265.3

p.R643insFs

c.1928_1929insA

2 papers

NM_003265.3

p.R643S

c.1927C>A

1 paper

NM_003265.3

p.P646P

c.1938C>T

2 papers

NM_003265.3

p.D648A

c.1943A>C

1 paper

NM_003265.3

p.C649S

c.1945T>A

1 paper

NM_003265.3

p.C649S

c.1946G>C

1 paper

NM_003265.3

p.C651S

c.1951T>A

1 paper

NM_003265.3

p.C651S

c.1952G>C

1 paper

NM_003265.3

p.E652*

c.1954G>T

2 papers

NM_003265.3

p.E652A

c.1955A>C

1 paper

NM_003265.3

p.S653R

c.1957A>C

1 paper

NM_003265.3

p.S653R

c.1959T>A