Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003265.3

p.Y733F

c.2198A>T

Surrounding Variants

1 paper

NM_003265.3

p.F732L

c.2196T>A

1 paper

NM_003265.3

p.F732L

c.2196T>G

1 paper

NM_003265.3

p.F732L

c.2194T>C

1 paper

NM_003265.3

p.V736V

c.2208T>A

9 papers

NM_003265.3

p.S737T

c.2209T>A

1 paper

NM_003265.3

p.S737*

c.2210C>A

1 paper

NM_003265.3

p.S737*

c.2210C>G

1 paper

NM_003265.3

p.W728*

c.2184G>A

1 paper

NM_003265.3

p.V738I

c.2212G>A

1 paper

NM_003265.3

p.W728*

c.2183G>A

1 paper

NM_003265.3

p.R740Q

c.2219G>A

4 papers

NM_003265.3

p.L742F

c.2224C>T