Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_003265.3

p.R811I

c.2432G>T

Surrounding Variants

1 paper

NM_003265.3

p.R811K

c.2432G>A

1 paper

NM_003265.3

p.K812R

c.2435A>G

1 paper

NM_003265.3

p.I807M

c.2421C>G

1 paper

NM_003265.3

p.A802E

c.2405C>A

1 paper

NM_003265.3

p.L821P

c.2462T>C

1 paper

NM_003265.3

p.L822delFs

c.2465_2466delTA

1 paper

NM_003265.3

p.E799E

c.2397A>G

1 paper

NM_003265.3

p.D824_L826delFs

c.2472_2476del5

1 paper

NM_003265.3

p.P825insFs

c.2473_2474ins4

1 paper

NM_003265.3

p.L826delFs

c.2477delT

1 paper

NM_003265.3

p.L826*

c.2477T>G

1 paper

NM_003265.3

p.L826F

c.2478A>C