Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.G869R

c.2605G>C

Surrounding Variants

1 paper

NM_003265.3

p.G869R

c.2605G>A

1 paper

NM_003265.3

p.R868R

c.2604A>G

6 papers

NM_003265.3

p.M870V

c.2608A>G

12 papers

NM_003265.3

p.R867Q

c.2600G>A

1 paper

NM_003265.3

p.M870I

c.2610G>A

1 paper

NM_003265.3

p.M870I

c.2610G>C

1 paper

NM_003265.3

p.M870I

c.2610G>T

6 papers

NM_003265.3

p.R867*

c.2599C>T

1 paper

NM_003265.3

p.N861fs

c.2581_2582fs

1 paper

NM_003265.3

p.Y858F

c.2573A>T

1 paper

NM_003265.3

p.P880Q

c.2639C>A

1 paper

NM_003265.3

p.V881V

c.2643T>C