Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.V33F

c.97G>T

Surrounding Variants

1 paper

NM_138554.5

p.V33I

c.97G>A

3 papers

NM_138554.5

p.V33A

c.98T>C

2 papers

NM_138554.5

p.V33G

c.98T>G

1 paper

NM_138554.5

p.V32A

c.95T>C

1 paper

NM_138554.5

p.P34A

c.100C>G

1 paper

NM_138554.5

p.P34L

c.101C>T

1 paper

NM_138554.5

p.P34P

c.102T>C

1 paper

NM_138554.5

p.I36F

c.106A>T

1 paper

NM_138554.5

p.I36I

c.108T>A

1 paper

NM_138554.5

p.T37insFs

c.110_111insC

1 paper

NM_138554.5

p.T37T

c.111T>A

1 paper

NM_138554.5

p.Y38C

c.113A>G