Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.I48I

c.144C>A

Surrounding Variants

1 paper

NM_138554.5

p.P49T

c.145C>A

2 papers

NM_138554.5

p.P49S

c.145C>T

1 paper

NM_138554.5

p.I48N

c.143T>A

1 paper

NM_138554.5

p.I48L

c.142A>C

1 paper

NM_138554.5

p.I48V

c.142A>G

1 paper

NM_138554.5

p.P49P

c.147C>T

1 paper

NM_138554.5

p.K47I

c.140A>T

2 papers

NM_138554.5

p.D50N

c.148G>A

1 paper

NM_138554.5

p.Y46Y

c.138C>T

6 papers

NM_138554.5

p.Y46C

c.137A>G

1 paper

NM_138554.5

p.N51D

c.151A>G

1 paper

NM_138554.5

p.N51S

c.152A>G