Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_138554.5

p.N58H

c.172A>C

Surrounding Variants

1 paper

NM_138554.5

p.N58Y

c.172A>T

2 papers

NM_138554.5

p.N58K

c.174C>G

2 papers

NM_138554.5

p.K57Q

c.169A>C

1 paper

NM_138554.5

p.L59P

c.176T>C

1 paper

NM_138554.5

p.T56_S62ins2

c.168_185dup18

1 paper

NM_138554.5

p.S55T

c.163T>A

1 paper

NM_138554.5

p.F54L

c.162C>A

2 papers

NM_138554.5

p.L61L

c.183G>A

39 papers

NM_138554.5

p.P53P

c.159C>T

1 paper

NM_138554.5

p.P53H

c.158C>A

1 paper

NM_003266.4

p.S22R

c.66C>G

1 paper

NM_138554.5

p.P53L

c.158C>T