Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.L69F

c.207A>T

Surrounding Variants

1 paper

NM_138554.5

p.L69F

c.207A>C

1 paper

NM_138554.5

p.G70A

c.209G>C

1 paper

NM_138554.5

p.G70G

c.210C>G

1 paper

NM_138554.5

p.H68Y

c.202C>T

1 paper

NM_138554.5

p.H68_G70del3

c.202_209del9

5 papers

NM_138554.5

p.S73R

c.217A>C

1 paper

NM_138554.5

p.L66Q

c.197T>A

1 paper

NM_138554.5

p.L66_R67insG

c.196_200ins3

1 paper

NM_138554.5

p.L66L

c.196C>T

5 papers

NM_138554.5

p.S73R

c.219C>A

5 papers

NM_138554.5

p.S73R

c.219C>G

1 paper

NM_138554.5

p.P65A

c.193C>G