Varaico: Literature-Extracted Genetic Variants

TLR4

2,554 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 55–114UCSCLeucine rich repeat

LRR_4aa 150–197UCSCLeucine Rich repeats (2 copies)

LRR_8aa 447–508UCSCLeucine rich repeat

Gene Aliases

HGNC Name

toll like receptor 4

HGNC Alias Symbols

hToll; CD284; TLR-4; ARMD10

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_138554.5

p.L80M

c.238C>A

Surrounding Variants

1 paper

NM_138554.5

p.E79K

c.235G>A

1 paper

NM_138554.5

p.P78R

c.233C>G

1 paper

NM_138554.5

p.P78A

c.232C>G

1 paper

NM_138554.5

p.P78S

c.232C>T

2 papers

NM_138554.5

p.V82M

c.244G>A

1 paper

NM_138554.5

p.F77L

c.231C>A

2 papers

NM_138554.5

p.F77L

c.231C>G

1 paper

NM_138554.5

p.V82E

c.245T>A

1 paper

NM_138554.5

p.V82A

c.245T>C

1 paper

NM_138554.5

p.V82G

c.245T>G

1 paper

NM_138554.5

p.F77L

c.229T>C

1 paper

NM_138554.5

p.S76R

c.228T>A